No. There were never enough Spanish settlers to replace the populace, and race mixing was obscenely common. Most of them are descendents of the Mayan/Aztec/Other remnants. You have to remember, that the Spainiards that came over here largely just enserfed the native population, converted them to Catholicism, and were declared subjects of the Spanish crown. There was never any ethnically pure cities or establishments, just military outposts to keep the conquered people toiling in silver and gold mines, and port cities.
That and the Spanish and Portugese had a ridiculous amount of territory available, so all attempts were poorly focused a,d thinly spread out. They were more about immediate gain of wealth than expanding thei own ethnic populations.
The Dutch, English and Germans took centuries of constant settling to make the East Coast what it was by 1750, constant settling and more importantly pure settling. They were setting up extensions of their nations outright, while the Spainiards and Portugese were content with a quick buck and religious converts.
The Iberian powers just wanted loot and converts. They had little interest in expanding the boundaries of their national peoples, and didn't have the demography even if they wanted to.
The Dutch had the desire, but never enough people, and eventually the Dutch East Indies became shitheaded enough that they permanently stunted the growth of Cape Colony which led to the history of the Trekkers. and while New York was originaly New Holland, again, the Dutch would have had to effectively shipped their entire nation overseas. Or at least, waaay too much to remain secure in their European wars.
So the Spanish never cared much for mass resettlement, which led the the indigenous population to having centuries of uninterrupted recovery time. Even accounting for the ones dying out so fast in the mines that niggers started getting imported en masse.
So by 1750 the natives, excluding Brazil, south of the Rio Grande, had recovered quite a bit.
Yeah, majority of the blood south of the rio grande is Injun.